A bio-nanocapsule containing envelope protein domain III of Japanese encephalitis virus protects mice against lethal Japanese encephalitis virus infection

Host defence mechanisms against Japanese encephalitis virus infection in mice.

The role of antibody and cell-mediated immunity in the resistance to Japanese encephalitis virus (JEV) infection was studied in adult mice. Passively transferred antibodies obtained up to 2 weeks after primary infection protected the recipient mice against a challenge infection with JEV. Antibody obtained at 4 or 5 weeks failed to protect despite the presence of high titres of neutralizing anti...

Congenital infection of mice with Japanese encephalitis virus.

Transplacental transmission of Japanese encephalitis virus (JEV) when given intraperitoneally was demonstrated in pregnant mice as shown by isolation of the virus from placenta and fetal tissues. Furthermore, JEV could be isolated from the brain, liver, and spleen of newborn mice. The effect of JEV at different periods of gestation in pregnant mice was demonstrated for the first time, and the c...

Monoclonal antibodies against NS4B protein of japanese encephalitis virus.

Japanese encephalitis (JE) is one of the most prevalent global viral encephalitis viruses. The functions of JEV (virus) NS4B protein are still under investigation. In our study, NS4B was expressed in Escherichia coli and purified by dialysis. Two clones of monoclonal antibodies (MAbs 1B1 and 1C3) against NS4B protein were generated and their characterizations were investigated. IFA, Western blo...

Neuropathogenesis of Japanese encephalitis virus.

In the central nervous system, the Japanese encephalitis virus can replicate only in neurons. The mechanism of the type of neurotropism was analyzed. The susceptibility to Japanese encephalitis virus infection in the rat brain was closely associated with neuronal immaturity. The initial specific binding of the virus to cells is one of the reasons for neurotropism of the Japanese encephalitis vi...

Immunobiology of Japanese Encephalitis Virus